11 Nov

Utility of Animal Models in the Study of Human Airway Disease: Rationale for the Usk of Animal Models

The most convincing reason for employing animal models is to address questions about the pathogenesis of airway hyperresponsiveness that cannot be answered in man. At a recent workshop sponsored by the National Heart, Lung and Blood Institute, the participants identified the major strengths and weaknesses of animal models (Table 1). Since airway hyperresponsiveness in animals is not a perfect copy of the airway hvperresponsiveness present in patients with bronchial asthma, both the scientist who employs an animal model and the clinician who tries to assess the relevance of observations made in animals should be aware of the strengths and weaknesses of the existing animal models. If animals with airway hyperresponsiveness are not viewed as complete models of human airway hvperresponsiveness but chosen to test a specific hypothesis concerning the pathogenesis of human bronchial asthma, the models can assume great scientific importance. A working knowledge of the biologic profile of the various animal models is therefore helpful. buy flovent inhaler

Table 1—Animal Models of Human Airway Hyperresponsiveness 

Strengths Weaknesses
Feasibility of invasive in vivo methods Natural hvperresponsiveness rare in animals
Availability of tissue for in vitro study Interspecies variability in lung anatomy can influence physiologic endpoints
Validation of data obtained in dispersed systems Interspecies differences in the pathogenesis of hvperresponsiveness
Ability to control and
manipulate genetic and
environmental influences
Preclinical testing of drugs

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