28 May

Infective Exacerbations of Chronic Bronchitis: Conclusion

One possible reason could be antibiotic pretreatment. There was a very strong correlation between antibiotic pretreatment and the recovery of group 3 organisms in sputum, with more pretreated patients harboring group 3 bacteria. However, the influence of antibiotic pretreatment on the distribution of bacteria groups among the different severity stages is probably limited, because the […]

26 May

Infective Exacerbations of Chronic Bronchitis: Outcome

In patients with acute exacerbations of COPD who require mechanical ventilation, 64% of the bacteria isolated by a protected specimen brush were Gram-negative bacteria, including P aeruginosa, Proteus mirabilis, and Escherichia coli in nearly a third. Unfortunately, in that study no data about lung function were provided, but the need for mechanical ventilation implies a […]

24 May

Infective Exacerbations of Chronic Bronchitis: Discussion

In the natural history of COPD, there is a steady, but individually variable decline in lung function parameters such as FEVp. Because FEVj is lower during acute infective exacerbations, we recorded FEVX for all patients after the symptoms of exacerbation had returned to baseline. We believe that it is feasible to differentiate the stages of […]

22 May

Infective Exacerbations of Chronic Bronchitis: Results

Data about steroid medication use were available in 98 patients. Fourteen patients (12.5%) had used inhaled steroids, 59 patients (52.7%) had taken systemic (oral) steroids, and 25 patients (22.3%) had not used any steroid medication. In 59 patients who took oral steroids, group 1 bacteria were found in 12 patients (20.3%), group 2 bacteria in […]

20 May

Infective Exacerbations of Chronic Bronchitis: Statistics

Statistics Categorical data (groups of bacteria versus stages of FEV1) were compared with 3X3 contingency tables and the x2 test (Pearson’s coefficient) using two-tailed p values. If the case number in one group was below 5, Fisher’s exact test was used. We compared continuous data with the analysis of variance test. Values of p<0.05 were […]

18 May

Infective Exacerbations of Chronic Bronchitis: Bacteriological Analysis

Sputum was collected in sterile sputum cups. After washing the oral cavity, patients were asked to expectorate sputum into the cup. Specimens were transported to the laboratory within 15 min of collection. A Gram’s stain of the sputum in the area of maximal purulence was examined for polymorphonuclear leukocytes and epithelial cells. Leukocytes and squamous […]

16 May

Infective Exacerbations of Chronic Bronchitis: Materials and Methods

Studij Population and Study Design We recorded the data of 211 unselected patients who were hospitalized in our department between 1990 and 1995. Patients were included in this study if they fulfilled the following criteria: diagnosis of a chronic mucopurulent and obstructive bronchitis according to the criteria of the American Thoracic Society , and historical […]

14 May

Infective Exacerbations of Chronic Bronchitis

Relation between Bacteriologic Etiology and Lung Function hronic bronchitis is a syndrome defined by cough and the abnormal production of sputum. Particularly in advanced stages, it is often complicated by airway obstruction, leading to the term chronic obstructive pulmonary disease (COPD). Currently, the pathogenesis of COPD remains unclear. Three factors appear to be important: cigarette […]

27 May

Chronic Inflammation Is Associated with an Increased Proportion of Goblet Cells Recovered by Bronchial Lavage (12)

BAL appears to be a more practical method for obtaining and evaluating bronchial epithelial cells than other available methods. Transbronchoscopic biopsies would seem much less practical, incur more risk, and are subject to sampling variability. It has been shown that while pathologic changes are consistent within a single bronchiole, there is significant variability among different […]

26 May

Chronic Inflammation Is Associated with an Increased Proportion of Goblet Cells Recovered by Bronchial Lavage (11)

Increased mucus from goblet cells may alter the surface active layer of bronchioles resulting in instability of the these peripheral airways and airways that would more easily close. buy birth control online There are several reasons to support the idea that the prevalence of BAL goblet cells is a reliable marker of long-term changes associated […]

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