14 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: CONCLUSIONS

After correction of these underlying causes through an increased dose of pancreatic enzyme therapy, the use of pH-sensitive pancreatic microsphere preparations, administration of an acid blocker and the improvement of compliance, an improved QoL was achieved in this group of patients, too. Significant correlations were found in both groups between the increase in the QoL […]

13 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: DISCUSSION (Part 2)

In the present study, the modified EORTC questionnaire was applied before and after enzyme replacement therapy in patients with chronic pancreatitis. We evaluated the QoL in two chronic pancreatitis patient populations: one group with newly diagnosed chronic pancreatitis who had never been treated, and another group who had already been treated with pancreatic enzyme therapy, […]

12 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: DISCUSSION (Part 1)

Chronic pancreatitis is a dynamic disease characterized by progressive destruction of the pancreatic parenchyma with fibrosis and calcification, and by pain and progressive impairment of the pancreatic functions . The 10-year mortality rate is unacceptably high . Despite recent advances in the conservative and operative treatment of chronic pancreatitis, the treatment of the disease remains […]

11 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: RESULTS (Part 2)

A significant gain in body weight was found in both groups one month after the beginning of pancreatic enzyme replacement therapy, compared with the pretreatment values. The defecation rate was significantly reduced by 22% in group 1 and by 17 % in group 2 during follow-up. The prevalence of general and disease-specific symptoms was reduced […]

10 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: RESULTS (Part 1)

The questionnaire was well accepted by the patient population (70% of whom were regular alcohol consumers) and it was completed by the patients themselves in approximately 15 mins, without difficulty. Compliance by patients in this study was very high (only one subject failed to complete the questionnaire), probably due to careful and detailed counselling of […]

09 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: Statistical analysis

An attached module with 22 specific items included a disease-specific symptom scale (items 31 to 48), a treatment strain scale (items 49 to 51), and an overall hope and confidence scale (item 52). Because the QLQ-C30 questionnaire does not contain any question on steatorrhea, the original questionnaire was supplemented with two additional questions covering this […]

08 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: Study design

The patients in both groups received dietary counselling and an enteric coated microsphere (1 to 2 mm in diameter) porcine pancreatic enzyme preparation three times a day. The enzyme replacement therapy depended on the grade of the exocrine pancreatic insufficiency; patients with a mild exocrine pancreatic insufficiency received a preparation with lower enzyme content (10,000 […]

07 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: Patients

The characteristics of the study sample are shown in Table 1. Eighty-nine consecutive patients were invited to participate in this study, and 75 of them consented, which corresponds to 86% of those invited. Five of the 75 enrolled patients were lost to follow-up; 70 patients completed the trial. Twenty-six, 24 and 20 patients were recruited […]

06 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: Patients inclusion criterion

Whereas the alleviation of steatorrhea and pain during pancreatic enzyme replacement therapy in chronic pancreatitis has been demonstrated , the effect of this treatment on QoL is not known. By employing the modified QLQ-C30 questionnaire in this prospective, multicentre, follow-up study, we have evaluated the QoL in patients with chronic pancreatitis who underwent pancreatic enzyme […]

05 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis (Part 2)

The QLQ-C30 incorporates nine multi-item scales: five functional scales (physical, role, cognitive, emotional and social); three symptom scales (fatigue, pain, and nausea and vomiting); and an overall health and QoL scale relevant to a broad range of cancer patients irrespective of the specific diagnosis. This core questionnaire has been supplemented by a diagnosis-specific symptom scale, […]

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