09 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (12)

Therefore, tachyphylaxis cannot be used as the major factor to explain the effectiveness of BN52021 in blocking the broncho-constrive effect of PAF. Thus, this is the first study demonstrating the efficacy of an aerosolized form of PAF antagonist in suppressing the immediate bron-choconstrictive response to PAF challenge in normal subjects and asthmatic children and bronchospasm […]

08 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (11)

As only the oral route of administration had been used in previous studies to examine the effect of PAF antagonists on PAF- and allergen-induced bronchoconstriction, we used an aerosol form in this study, hoping to achieve the maximal effect with fewer side effects. Our results showed that inhalation of five puffs of BN52021 at a […]

07 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (10)

Recently, PAF has been postulated to play a central role in the pathogenesis of bronchial asthma because PAF is unique, among allergic mediators, by having the capacity to induce protracted inflammation of the type that is evident in asthma, ie, infiltration of the airways by mononuclear cells, neutrophils, and eosinophils. This unique inflammatory process, which […]

06 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (9)

In addition, BN52021 was less efficient in inhibiting the PAF-induced bronchoconstriction in patients than in normal subjects, especially at low concentration. Rubin et al also reported a greater decrease of FEVi at 1,000 mg/L of PAF in asthmatics (10 percent) than in normal subjects (5 percent), and the asthmatic responders were approximately four times more […]

05 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (8)

Figure 3A shows that inhalation of mite allergen extract-induced bronchospasm in all of seven mite-sensitive asthmatic children. Importantly, the allergen-induced bronchoconstriction could be inhibited by a prior inhalation of BN52021 in three of seven patients (Fig 3B), and the threshold of allergen sensitivity was increased in each patient after inhalation of BN52021.

04 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (7)

BN52021 at the concentration of 50 ng/ml had only a little effect on PAF-induced bronchospasm; at a concentration of 150 ng/ml, BN52021 could inhibit PAF-induced bronchospasm in four of the six responders and at a concentration of450 ng/ml, BN52021 was capable of preventing PAF-induced bronchospasm in all six responders. However, as the dose-response study of […]

03 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (6)

The total WBC, neutrophil, and eosinophil counts were checked before challenge and at 5 and 10 minutes after the completion of PAF challenges. Symptoms such as throat irritation, cough, flushing, dyspnea, and tachycardia were recorded during the test and within the 24 h after challenge. antibiotics levaquin Statistics Data were expressed as mean ± SD […]

02 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (5)

BN52021 remained soluble in HBSS when cooled to room temperature before use. HBSS containing DM SO of lOMold dilution (weight/volume) was used as placebo. As both BN52021 and DMSO were highly diluted, no evident bitter taste or odor could be detected. Moreover, only those who showed less than 10 percent decrease in FEV, after inhaling […]

01 Apr

Allergen-Induced Bronchoconstriction in Asthmatic Children (4)

To obtain a dose response of BN52021 on the one hand and to avoid tachyphylaxis to PAF on the other hand, PAF challenge was done for four consecutive days, pretreated each day blindly with either placebo or one of the three concentrations of BN52021 (see below), respectively. buy cheap antibiotics

31 Mar

Allergen-Induced Bronchoconstriction in Asthmatic Children (3)

Asthmatic children were selected as stable if they had not had an asthmatic attack in the last month, they had not taken medication in the last two weeks, and their forced expiratory volume in 1 s (FEV,) was at least 80 percent of the predicted normal. Healthy subjects had normal pulmonary (unction and had had […]

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