14 Aug

Canadian Health and Care Mall: Pharmacodynamics of Theophylline

Asthma The various studies published on the efficacy and toxicity of theophylline have led to a carefully defined range of serum concentrations, between 10 and 20 fjig/ml, where there is an optimal likelihood of maximal safe effect. It is this optimal range for maximal safe effect that has been commonly termed the “therapeutic range. The […]

17 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Conclusion

Findings relating to TG vary widely in different studies. According to Kelemen et al2 the TG was 0.042 ± 0.005 s, while according to Ross et al it was 0.2 s and according to Yanaghihara et al, 0.09 to 0.34 s. Our findings confirm this substantial variation. In addition, there seems to be a positive […]

16 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Discussion

The groups for the present study were selected with the purpose of studying patients with different pathophysiologic basis of cough: asthma with variable bronchial obstruction, bronchitis with expectoration or infection or both, TBCS with pathologic bronchial dynamics, and FPD with reorganization of the pulmonary tissue. Since the patients were breathing through a mouthpiece, we recorded […]

15 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Asthmatic patients

Occasionally, an expiration was interrupted by cough, without immediately preceding inspiration, an average 1,713 ± 859 ms after the start of expiration. We therefore termed them end-expiratory coughs (Fig 6). The incidence of end-expiratory cough in the patient groups is represented in Table 2. Asthmatic patients had the highest percentage of end-expiratory coughs of all […]

14 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Results

An average of 12.4 ± 6.2 (mean ± SD) coughs (range, 4 to 27) were recorded from each patient. Typically, a cough reflex comprised deep inspiration followed by glottic closure, glottic opening and rapid expiratory flow (CPEF) (Fig 2). However, one cough could include several opening and closing phases without intermittent inspirations. The sounds always […]

13 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Methods

Methods The recording of cough was performed in an acoustically isolated chamber with the patient sitting. Breathing air was conducted through a pneumotachograph (Fleisch) and the nose was shut. Sounds of spontaneous cough were recorded from the sternal manubrium with a condenser microphone (B&K 4134) mounted in a plastic piece attached to the skin with […]

12 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases: Patients and Methods

In the five patients with acute bronchitis, symptoms had lasted from one to four weeks before the recording. One patient also had rheumatoid arthritis and another patient arterial hypertension. The findings of dynamic spirometry were normal in four patients but showed moderately diminished vital capacity in one. Bronchoscopic studies were not performed. The chest x-ray […]

11 Nov

Differences in Acoustic and Dynamic Characteristics of Spontaneous Cough in Pulmonary Diseases

Cough is one of the most common symptoms of pulmonary disease. Its properties are not, however, clinically consistent from one disease to another. Few objective studies have been published on the acoustic or dynamic patterns of cough; most studies deal with intensity analysis or tussiphonography of voluntary cough. One study has analyzed the spectral contents […]

05 Oct

Characteristics of Asthma Care Provided by Hospitals in a Large Metropolitan Area: Conclusion

Although there are important limitations, this survey still provides new insights into the asthma care delivered by a large group of hospitals located in one geographical area. Several audits of hospital-based asthma care conducted outside of the United States have been published; however, these studies almost exclusively examine individual hospital performance rather than taking a […]

04 Oct

Characteristics of Asthma Care Provided by Hospitals in a Large Metropolitan Area: Outcome

Asthma programs that include a home visit for follow-up after discharge have shown promise as effective strategies to reduce readmission. However, very few hospitals provide any type of asthma case management or home visit services. This lack of coordinating services at the hospital level is counter to the emerging interest of managed care to develop […]

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