10 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: RESULTS (Part 1)

exocrine pancreatic insufficiency

The questionnaire was well accepted by the patient population (70% of whom were regular alcohol consumers) and it was completed by the patients themselves in approximately 15 mins, without difficulty. Compliance by patients in this study was very high (only one subject failed to complete the questionnaire), probably due to careful and detailed counselling of the patients.

Patients in group 2 had significantly more severe exocrine pancreatic insufficiency as measured by functional tests, and greater steatorrhea when compared with group 1. More patients underwent surgical therapy in group 2 than in group 1, and all the patients in group 2 failed to respond to medical therapy. Therefore, the patients in group 2 appeared to have more severe chronic pancreatitis.

The pretreatment and follow up QoL scores for each scale are displayed in Tables 2 and 3. Although the baseline score of social functioning and financial strain were significantly better, the hope and confidence were significantly reduced in group 1 compared with group 2. At one month, the social functioning and financial strain were not significantly different between the two groups. Before the start of the study, the mean body weight loss was 7.4±1.8 kg in group 1 and 4.7±1.3 kg in group 2. Find most trusted pharmacy that will give you Inhalers for Asthma in the amounts required without any need for a prescription. You will see that shopping with a place you can already trust over and over again is very affordable and always nice.

TABLE 2 Results of quality of life scores in group 1

Scales Items Pretreatment score Follow-up score Significance
Body weight (kg) 67.7±3.8 67.9±3.1 P=0.049
Defecation/week 12.1±1.1 9.4±0.8 P=0.023
Physical status 1-5 81.3 84.5 P=0.190
Working ability 6,7 77.4 82.3 P=0.043
General symptoms 8-19 47.4 (11.1-88.8) 33.9 (0-86.1) P=0.000
Cognitive 20,25 66.1 73.6 (16.6-100) P=0.042
Emotional 21-24 43.0 48.6 P=0.150
Social 26,27 81.2 79.0 P=0.505
Financial strain 28 59.1 67.7 P=0.004
Global quality of life 29,30 43.9 (8.3-66.6) 53.3 (33.3-83.3) P=0.005
Disease-specific symptoms 31-48 28.8 (1.3-72.2) 23.3 (0-55.5) P=0.003
Treatment strain 49 58.0 (16.6-100) 64.4 (33.3-100) P=0.310
Hope and confidence 52 25.6 (0-66.6) 23.7 (0-66.6) P=0.399
Pain 9, 19, 38, 41-46 47.1 (0-90.5) 35.9 (0-90.5) P=0.001

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