07 Aug

Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis: Patients

The characteristics of the study sample are shown in Table 1. Eighty-nine consecutive patients were invited to participate in this study, and 75 of them consented, which corresponds to 86% of those invited. Five of the 75 enrolled patients were lost to follow-up; 70 patients completed the trial. Twenty-six, 24 and 20 patients were recruited by the participating institutions, respectively, which were tertiary academic centres.

Two groups of patients were evaluated. Group 1 consisted of patients with newly diagnosed chronic pancreatitis who had never been treated with pancreatic enzyme preparations (31 patients, 29 men and two women, mean age 53.0 years, range 31 to 79 years). Group 2 consisted of patients whose disease was diagnosed on average 3.4 years (range one to 14 years) before the start of this study (39 patients, 37 men and two women, mean age 53.2 years, range 35 to 72 years). Group 2 underwent pancreatic enzyme replacement therapy, but during the follow-up this treatment proved to be insufficient. All group 2 patients presented with abdominal pain, weight loss and steatorrhea (Table 1). Your online shopping could cost you less and less time, you just need a reliable pharmacy to buy tadalafil online and be sure this one will always live up to your expectations.

The etiology of the chronic pancreatitis involved alcohol overindulgence in 22 patients in group 1, and 28 patients in group 2. Three and 11 patients, respectively, had previously undergone pancreatic surgery (the Whipple or the Beger procedure, cystogas-trostomy, cystojejunostomy or Wirsungo-gastrostomy) in groups 1 and 2, while six and nine patients suffered from diabetes mellitus in groups 1 and 2, respectively (Table 1).

TABLE 1 Characteristics of the study patients

Group 1 Group 2
Number of patients 31 39
Age 53.0 53.2
Sex (male/female) 29/2 37/2
Chronic alcoholism 22 28
Diabetes mellitus (yes/no) 6/25 9/30
Pancreatic operation (yes/no) 3/28 11/28
Clinical symptoms (yes/no)
Pain 30/1 37/2
Steatorrhea 12/19 23/16
Bloating 28/3 34/5
Defecation/week 12.1±1.1 13.9±1.8
Degree of exocrine pancreatic insufficiency (mild/severe) 20/11 14/25

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