06 Mar

Pulmonary Rehabilitation in Patients with COPD: Results (2)

The data of the exercise tests before and after the training period are summarized in Table 3. The 12-minute walking distance improved in both groups, but it improved significantly more in the PR + IMT group than in the PR group (p<0.05, MWU test). In both groups, maximal work load on the bicycle ergometer, Vo2, and Vco2 at maximal exercise, and VEmax increased significantly. For all these changes, there were no significant differences between the two groups. The heart rate at maximal exercise remained unchanged during the training period, indicating a real training effect.
Baseline PaC02, as well as the increase in Pco2 during the exercise test, was not changed after the training period (Table 4). antibiotic levaquin
The ADL scores increased in both groups to the same extent (Table 5). Baseline scores on anxiety, depression, and physical complaints were significantly increased compared with the predicted values. In both groups, there was a significant improvement in these scores, without differences between the two groups.

Table 3—Exercise Test Results

Baseline 10 wk p Value
Walking distance, m
PR 1057 ±284 1251 ±354 <0.01
PR + IMT 1046 ±323 1309 ± 376t <0.01
Wmax, watt
PR 97 ±44 127 ±55 <0.01
PR+IMT 93±54 116±59 <0.01
HRmax, beats/min
PR 138 ±16 138 ±17 NS
PR+IMT 134 ±19 137 ±24 NS
Vot, max, IVmin
PR 1.46±0.50 1.62 ±0.58 <0.01
PR + IMT 1.37 ±0.53 1.47 ±0.63 <0.01
VEmax, L/min
PR 49.5 ±15.6 56.1 ±18.8 <0.01
PR+IMT 46.8 ±19.6 51.1 ±21.3 <0.01

Table 4—Fa CO, Values at Rest and at Maximal Exercise

Baseline 10 wk
Resting Maximal Resting Maximal
PaCO,, kPA PRPR + IMT 5.0    ±0.55.0    ±0.5 6.1 ±0.4 6.0 ±0.3 5.3 ±0.7 5.0 ±0.5 6.1    ±0.46.2    ±0.3

Table 5—Activities in Daily Life (ADL) and Psychologic Scores before and after the Training Period

Baseline 4 wk 10 wk
ADL scores PR 6.3 ±2.3 6.9 ±2.3 7.7±2.3
PR + IMT 6.2 ±2.4 7.2 ±2.3 8.4±2.2
Anxiety PR 15.4±4.9 12.8±2.9
(rv, 13.0) PR + IMT 17.5±8.2 14.6±6.4
Depression PR 24.7±8.9 20.8 ±5.0
(rv, 20.0) PR + IMT 28.4±11.5 24.4 ±9.5
Physical PR 21.1 ±6.4 17.9±3.7
complaints (rv, 16.6) PR + IMT 23.1 ±8.2 20.0 ±7. 1

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