21 Sep

Persistent upper gastrointestinal symptoms despite proton pump inhibitor therapy: Results (Part 1)

An overview of the validation process for the PASS test is provided in Figure 2.

Initial identification of symptoms and potential PASS questions

Analysis of the telephone survey, completed by 150 patients, indicated that 47% of patients supplemented their PPI with an over-the-counter medication. Stomach-related problems reported by these patients included sleeping (50%), eating (47%), work or daily activities (23%), social and exercise activities (17% to 18%) and hobbies (15%). The main spontaneously reported GI symptoms were pain or heartburn, indigestion and acid taste or fluid in the mouth or throat, occurring in 65%, 35% and 29% of cases, respectively. The most bothersome symptoms were heartburn (25%) and acid reflux (22%), followed by epigastric or stomach pain (13%).

As a result of this survey, five items were selected for the draft PASS test.

Content validity

The survey was completed in English by 20 patients (mean age 61 years; four men) and in French by 16 patients (mean age 59 years; 10 men). Nineteen patients in the English group and 15 in the French group were taking a PPI one to three times a day before the study.

Overview of the process of validation

Figure 2) Overview of the process of validation for the Proton pump inhibitor (PPI) Acid Suppression Symptom (PASS) test with the accomplishments of each stage. GI Gastrointestinal 
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