Management of polycystic liver disease: PATHOGENESIS
The pathogenesis of PCLD is incompletely understood. PCLD cysts are believed to originate from biliary epithelium or the hepatic lymphatic system. Everson et al found that PCLD cyst epithelium had the functional characteristics of biliary epithelium. They found that hepatic cystic fluid, similar to biliary epithelial fluid, contained secretory IgA and low glucose concentrations, and may be secreted in response to secretin. Histological studies have shown that hepatic cysts originate from either biliary microhamartomas separate from the biliary tract or from peribiliary glands, and dilate over time to become gross cysts. This finding has been seen in both isolated PCLD and PCLD associated with PCKD. Once cysts develop, enlargement of pre-existing cysts appears to contribute more to hepatic enlargement rather than the development of new cysts. Although the pathogenesis of isolated PCLD is similar to that of PCLD associated with PCKD, they have different genetic origins. Autosomal dominant PCKD has been linked to PCKD gene 1 and 2 mutations. Recently, mutations in the protein kinase C substrate 80K-H gene encoding for hepa-tocystin have been described to be associated with autosomal dominant PCLD. Choose a perfect online pharmacy to get levitra professional sale here and treat your health issue.