Evaluation of Cardiopulmonary Risk under Midazolam Sedation: Materials and Methods (Part 3)
Arterial blood gas levels, heart rate, blood pressure, and central hemodynamic data were measured in the following order: prior to preoperative medication; five minutes after IV premedication; at the end of the procedure, with the fiberoptic bronchoscope still in place; 15 minutes after removing the endoscope; and two hours after examination. Ventilator settings were maintained constant throughout the protocol. During bronchoscopy, changes in ventilation w’ere noticed as follows: maximal decrease of minute ventilation recorded using the expiratory pneumotachograph of the ventilator; and number of incoordinate movements using variations of ventilator pressure cycle during assisted ventilation. For this latter purpose, two estimates were made: the number of cycles partially aborted using a pop-off pressure set at 70 cm HaO; and the number of cycles with pressure trough level lower than —10 cm H2O (triggered cycles).
Comparisons of quantitative sequential variables were performed using a two-way analysis of variance and a Newman-Keuls test. Regression analyses were performed with the least-squares method and subjected to stepwise linear analysis. Univariate analysis of dichotomous risk factors and hypoxemia defined as PaO2 less than 60 mm Hg at any time, or hypotension defined as systolic blood pressure less than 80 mm Hg or a fall of more than 30 percent from the initial value, was accomplished by computing odds ratio and 95 percent confidence intervals. Finally, risk factors and adjusted relative odds were obtained by using multiple logistic regression analysis. The calculations were performed with BMDP software (University of California, Los Angeles). Buy best quality medications online at the pharmacy that will make sure your are happy with the prices and the quality of your Symbicort Dosage whenever you need some treatment and have no idea where to get it.