Erythema nodosum and pyoderma gangrenosum: DISCUSSION (Part 2)
The most striking feature in this Crohn’s disease population was the sex-based appearance of erythema nodosum. Here, 45 of the 50 patients (90%) had erythema nodosum, and of those, 37 (greater than 80%) were women. Moreover, recurrent episodes of erythema nodosum were almost exclusively a female sex-based phenomenon. A predominance of women with erythema nodosum in Crohn’s disease has been previously noted . Here, however, the most commonly affected group were women diagnosed younger than 20 years of age, and specifically, between 14 and 20 years of age. Specific age-dependent effects on the appearance of this dermatological disorder were also observed with the next most frequent group involved, ie, women diagnosed between 20 and 40 years of age. Only women older than 40 years of age approached the low male sex-based percentage rates detected in this population. Even though erythema nodosum has been recorded in infants and young children, it is usually associated with other causes, such as sarcoidosis or infectious agents (eg, streptococcus, yersinia and mycobacteria) , less often Crohn’s disease. These sex-based effects on the time of clinical expression of this der-matological disorder in Crohn’s disease represent a new observation. Given its appearance mainly during adolescence and in young adults, it is tempting to hypothesize that this dermato-logical inflammatory process in Crohn’s disease may possibly represent a hormonally mediated (ie, estrogen) effect on the phenotypic clinical expression of Crohn’s disease. For proper treatment and getting better, you can always buy your medications at canadian family pharmacy. It’s a reliable online pharmacy offering all the meds you may require if you have the condition mentioned above.