20 Aug

Effect of Vitamin E on Exhaled Ethane in Cigarette Smokers: Outcome

Effect of Vitamin E on Exhaled Ethane in Cigarette Smokers: OutcomeThus, a wide variability in micronutrient levels would be expected, and the resultant effects on ethane production would be variable as well. However, once antioxidant levels are raised by supplementation such that they are high and the antioxidant effects are at their maximum, variations in ethane would be the result of oxidant effect rather than antioxidant effect. Under this scenario, the negative relationship between exhaled ethane and lung function would be exposed as it appears to be from both of our studies. Examination of Figure 3, center (B), also reveals less scatter of ethane values than can be found in any of the other panels of Figure 3 supporting our hypothesis. Additional support for this hypothesis comes from the observation that 3 weeks after these subjects had resumed their previous nutritional habits with no further supplementation, no correlation was found between vitamin E levels and lung function (Fig 3, bottom, C) read asthma inhalers. To further support the above contention, the analysis comparing pack-years with exhaled ethane also shows statistical significance only after vitamin E supplementation (Fig 1, center, B).
Although the reduction in ethane after vitamin E supplementation was not statistically significant, a trend for a negative association between measures of lung function and the changes in lung ethane is to be noted (Fig 4). This result is consistent with our previous observation in which the reduction in exhaled ethane induced by vitamin E, vitamin C, and P-carotene correlated significantly with preserved lung function in smokers. We explain the absence of a statistically significant correlation as follows: first, we found that vitamin E alone does not lower ethane levels as much as a combination of the agents or even one of the other nutrients.

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