Archive for the 'Helicobacter pylori infection' Category

26 Aug

The role of Helicobacter pylori infection as a cause of dyspepsia (Part 4)

Evidence that pro-inflammatory cytokines, such as interleukin (IL) -1P and IL-6, suppress acetylcholine release from nerve terminals , suggests a possible mechanism for the observations of Bercik et al. In addition, because the cells of the enteric nervous system lie in close proximity to immune cells, inflammatory mediators released during infection, such as bradykinin and […]

25 Aug

The role of Helicobacter pylori infection as a cause of dyspepsia (Part 3)

Both human and animal studies demonstrate a link between mucosal inflammation and changes in sensory-motor function in the small intestine and colon. However, little attention had previously been given to the stomach. Bercik et al demonstrated altered neuromuscular function in the stomach and changes in spinal neuropeptide expression associated with chronic inflammation induced by H […]

24 Aug

The role of Helicobacter pylori infection as a cause of dyspepsia (Part 2)

Immunostaining of gastric sections showed increased density, but no change in the distribution, of substance P, calcitonin gene-related peptide and vasoactive intestinal peptide nerve fibres in chronically infected mice. Substance P and calcitonin gene-related peptide, but not vasoactive intestinal peptide, containing nerve fibre densities also were increased in the spinal cord following chronic gastric infection. […]

23 Aug

The role of Helicobacter pylori infection as a cause of dyspepsia (Part 1)

The relationship between gastric inflammation caused by Helicobacter pylori infection and symptoms of dyspepsia remains controversial . Using a murine model of gastric infection, Bercik et al provide new insights into the mechanism underlying such interactions. Gastric sections from Balb/c mice infected with H pylori, strain SS-1, were used for both histological evaluation and studies […]

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