Archive for the 'Erythema nodosum and pyoderma gangrenosum' Category

26 Sep

Erythema nodosum and pyoderma gangrenosum: DISCUSSION (Part 2)

The most striking feature in this Crohn’s disease population was the sex-based appearance of erythema nodosum. Here, 45 of the 50 patients (90%) had erythema nodosum, and of those, 37 (greater than 80%) were women. Moreover, recurrent episodes of erythema nodosum were almost exclusively a female sex-based phenomenon. A predominance of women with erythema nodosum […]

21 Sep

Erythema nodosum and pyoderma gangrenosum: DISCUSSION (Part 3)

Interestingly, estrogen-mediated effects on adipose tissue cytokines have also been observed by others and modulatory effects of estrogen on cytokines involved in murine models of colitis have been described . Further investigative studies to explore the role of sex steroids, particularly female hormones, including exogenous sources (eg, contraceptive medication) on the clinical expression of Crohn’s […]

04 Sep

Erythema nodosum and pyoderma gangrenosum: DISCUSSION (Part 1)

Dermatological disorders are among the most commonly detected extraintestinal manifestations in Crohn’s disease . In the present population-based evaluation using prospectively accumulated data in Crohn’s disease, erythema nodosum and pyoderma gangrenosum were seen in 4.9% and 0.7% of patients, respectively. These results in consecutively evaluated patients with Crohn’s disease accumulated for more than two decades […]

03 Sep

Erythema nodosum and pyoderma gangrenosum: Disease behaviour

Table 1 shows the percentages of patients in this population classified with different types of disease behaviour. For each of the different age groups, most patients suffered from complex clinical disease with strictures or penetrating complications. Figure 4 shows the percentage of different disease behaviour patterns in each age group with Crohn’s disease that were […]

02 Sep

Erythema nodosum and pyoderma gangrenosum: Disease site (Part 2)

Figure 3 shows the percentage of patients with erythema nodosum and/or pyoderma gangrenosum in each age group for each site of disease involvement. Most had colonic involvement either alone or, more often, combined with ileal involvement, consistent with previous reports . Although there were some that had ileal disease alone, even those classified with upper […]

01 Sep

Erythema nodosum and pyoderma gangrenosum: Disease site (Part 1)

Table 1 shows the percentage of patients in each age group based on disease location as defined by the modern Vienna schema , but modified to permit evaluation of patients diagnosed younger than 20 years of age . As shown, patients diagnosed younger than 20 years of age had more extensive disease, usually with ileocolonic […]

31 Aug

Erythema nodosum and pyoderma gangrenosum: Patient age (Part 2)

Figure 2 shows that for each of the groups with Crohn’s disease with these dermatological disorders, a greater percentage of women were affected for each age group at diagnosis (all P<0.05). There were 18 patients diagnosed at younger than 20 years of age (16 of 128 women and two of 96 men), 29 diagnosed between […]

30 Aug

Erythema nodosum and pyoderma gangrenosum: Patient age (Part 1)

Figure 1 shows patient age at diagnosis. For the entire group of 1015 patients, 846 (83.3%) were diagnosed younger than 40 years of age and 169 (16.7%) were diagnosed older than 40 years of age (P<0.05). These results from a continuously accumulating patient database are similar to previously published results using this modern Vienna classification […]

29 Aug

Erythema nodosum and pyoderma gangrenosum: RESULTS Patient group

Figure 1 shows the entire population of 1015 Crohn’s disease patients evaluated directly by the clinician investigator for more than two decades. As shown for each age group, there was a predominantly female pattern. In the database, there were a total of 50 patients (4.9%) with erythema nodosum and/or pyoderma gangrenosum. This included 45 patients […]

28 Aug

Erythema nodosum and pyoderma gangrenosum: Classification method

Male and female patients were each classified based on a previously published schema developed elsewhere, that was previously applied by the author to a single-clinician Crohn’s disease database. For the present evaluation, however, a modification of the Vienna schema was necessary to create a younger than 20 years of age group; this classification schema does […]

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