Archive for the 'Cytotrophoblast' Category

19 Feb

Activated Macrophages Inhibit Human Cytotrophoblast: DISCUSSION

The results of this study provide evidence that activated macrophages inhibit the ability of an immortalized line of cytotrophoblasts to invade through ECM in vitro. In addition, the present findings revealed that nonactivated macrophages were unable to inhibit invasion, thereby providing evidence that the anti-invasive effect of macrophages does not occur via a nonspecific direct […]

17 Feb

Activated Macrophages Inhibit Human Cytotrophoblast: RESULTS

Effect of Activated Macrophages and TNF on Cytotrophoblast Invasion To determine the role of activated macrophages on cytotrophoblast invasion, HTR-8/SVneo cells were cocultured with various ratios of LPS-activated macrophages or nonactivated macrophages isolated from the peripheral blood of five healthy donors. There were no noticeable differences in the results obtained using leukocytes collected from the […]

15 Feb

Activated Macrophages Inhibit Human Cytotrophoblast: MATERIALS AND METHODS

Cells The HTR-8/SVneo cell line was used in these experiments. This is an immortalized human trophoblast cell line established after transfection of first trimester primary trophoblasts with a cDNA that encodes the SV40 large T antigen. Although the HTR-8/SVneo cells are nontumorigenic and nonmetastatic when transplanted into athymic mice, they are highly invasive in vitro […]

13 Feb

Activated Macrophages Inhibit Human Cytotrophoblast: INTRODUCTION

Extravillous cytotrophoblast invasion and remodeling of the uterine spiral arterioles are important aspects of normal placentation. By modifying these vessels, invasive tropho-blast cells ensure unimpeded blood flow to the placenta, which is critical for proper fetal development. In contrast to normal pregnancy, trophoblastic remodeling of the uterine spiral arterioles is diminished in virtually all cases […]

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