Archive for the 'COPD' Category

13 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Conclusion

Our results suggest that inhaled NO should be studied as a supplement to oxygen therapy for the short-term treatment of acute exacerbations of pulmonary hypertension in patients with severe COPD. They further suggest that although a dose-dependent response of the pulmonary circulation could be anticipated, there is a ceiling effect on oxygenation at low levels […]

11 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Outcome

In contrast, pulmonary hemodynamics continued to improve as the NO concentration was increased from 5 through 20 ppm, demonstrating dose dependence. The mechanism appeared to be NO-induced pulmonaiy vasodilatation leading to a reduction of MPAP and improved REF. Because the HR remained unchanged, we surmise that the increase in Cl was due to improved REF. […]

09 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Pulmonary vascular resistance

However, although NO led to a consistent and dose-dependent decrease in pulmonary vascular resistance, the mean Pa02 increased significantly at 40 ppm only, and then only from 57±3 to 60±3 mm Hg (p<0.01). In fact, in 4 of the 13 patients, Pa02 actually declined. In a study on inhaled NO at 15 ppm in a […]

07 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Discussion

Several trials of domiciliary LTOT have demonstrated a considerable improvement in exercise tolerance and neuropsychological function, as well as a reduction in the requirement for hospitalization. Although no significant change of MPAP was observed in the Medical Research Council study in patients receiving LTOT for 15 h/d, a regimen delivering oxygen for 18 h/d over […]

05 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Results

Mean values of hemodynamic variables are shown in Table 2. Inhaled NO did not significantly alter the systemic circulatory indexes HR, MAP, pulmonary capillary wedge pressure, or SVRI at any level of NO concentration. However, Cl, which remained unchanged with 5 ppm NO, did increase by 9% at 10 ppm and by 12% at 20 […]

03 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Hemodynamic

All patients were observed on-line with ECG, invasive BP monitoring, and measurement of peripheral oxygen saturation (Hewlett Packard; Boblingen, Germany). Cardiac index (Cl) was calculated using the thermodilution technique and expressed as the mean of the values recorded from four 10-mL injections of iced saline solution at 1 to 5°C. my canadian pharmacy online The […]

01 Jun

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD: Materials and Methods

However, previous studies in COPD patients have suggested that although pulmonary vascular resistance is consistently decreased by NO inhalation, V/Q matching is unaffected or even worsened. It has been suggested that NO may reverse hypoxic pulmonary vasoconstriction in those patients in whom this mechanism preserves V/Q matching. In these studies, the results of NO inhalation […]

30 May

Addition of Nitric Oxide to Oxygen Improves Cardiopulmonary Function in Patients With Severe COPD

Persistent or episodic hypoxemia in patients with COPD leads to the development of pulmonary hypertension, which is exacerbated by exercise and episodes of acute inflammation. Pulmonary hypertension in COPD patients is associated with a worsened survival rate. When pulmonary hypertension is observed in COPD patients, mean pulmonary arterial pressure (MPAP) generally increases into the range […]

12 May

COPD: Overview of Definitions, Epidemiology, and Factors Influencing Its Development: Conclusion

In this regard, it is reasonable to consider the process of emphysema. As noted above, current concepts suggest that damage of the alveolar structures results in destruction of alveolar walls, and hence, emphysema. Excess of proteases, for example elastase released by neutrophils in excess of antipro-teolytic protective mechanisms such as ar-protease inhibitor, can lead to […]

10 May

COPD: Overview of Definitions, Epidemiology, and Factors Influencing Its Development: The British and Dutch Hypotheses

Among the other factors associated with accelerated rate of decline in lung function are two that have been the subject of considerable debate: mucus hyperproduction and bronchial hyperresponsiveness (Fig 2). The first of these, mucus hyperproduction, is associated with the “British hypothesis” which suggests that the overproduction of mucus was associated with chronic airways inflammation. […]

© 2017 - Men’s Health Info Blog