Aryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(5)
The infiltrating leukocytes were identified to be neutrophils. These histopatho-logical features of N-9 observed in this study are similar to those observed in the rat model. That repetitive intravaginal infusion of WHI-07 does not cause a detergent-type membrane injury or an acute inflammatory response in the cervicovaginal epithelium, as demonstrated by our studies, may prove clinically advantageous. Future preclinical studies will examine intravaginally applied WHI-07 for potential systemic effects, especially those on female genital tract and reproductive function as well as early embryonic development and fetal morphogenesis. canadian family pharmacy
The development of novel aryl phosphate derivatives of bromo-methoxy-AZT with potent spermicidal and anti-HIV activities represents a significant step forward in the development of a new virucidal spermicide for curbing heterosexual HIV transmission. The promising results reported herein warrant the further development of these dual-function AZT derivatives as a new class of vaginal contraceptives capable of preventing the sexual transmission of HIV while providing fertility control for women who are at high risk for acquiring HIV by heterosexual transmission. These dual-function AZT derivatives may also have utility in curbing domestic and wildlife animal retroviral transmissions.