Aryl Phosphate Derivatives of Bromo-Methoxy-Azidothymidine: DISCUSSION(4)
Fertilization in vivo depends upon successful sperm transport through the female genital tract. Results of our in vivo contraceptive efficacy studies in the mouse model demonstrated that prior exposure of artificially inseminated epididymal sperm to WHI-07 via cervix significantly affected sperm fertilizing ability in vivo in hormonally primed female mice, indicative of the inability of WHI-07-exposed sperm to reach the site of fertilization. The results of this pilot study indicate that WHI-07 would be an attractive candidate for further contraceptive efficacy trials in larger animal models. buy ventolin inhalers
Experiments designed to test the comparative local toxicity of N-9 versus WHI-07 clearly demonstrated that, unlike what occurs with the intravaginally applied N-9, repetitive intravaginal application of WHI-07 did not induce an inflammatory response by detergent-type disruption. Evidence obtained by histopathologic and immunofluorescence studies suggests that intravaginal application of N-9 caused marked underlying acute inflammatory response in the cervicovaginal epithelial crypts.