31 Mar

Allergen-Induced Bronchoconstriction in Asthmatic Children (3)

Allergen-Induced Bronchoconstriction in Asthmatic Children (3)Asthmatic children were selected as stable if they had not had an asthmatic attack in the last month, they had not taken medication in the last two weeks, and their forced expiratory volume in 1 s (FEV,) was at least 80 percent of the predicted normal. Healthy subjects had normal pulmonary (unction and had had no respiratory tract infection in the previous two weeks. Informed consents were obtained from the parents before the children were enrolled into the study. The asthmatic children were divided randomly into three groups (seven patients in each group). The characteristics of each group, including the control group (healthy children), are listed in Table 1. birth control yasmin

Experimental protocol
Each patient group was challenged with only one of the following stimulants: PAF, methacholine, and mite allergen. The control group performed PAF challenge. The effects of aerosol BN52021 on PAF, methacholine, and allergen challenges were studied using a double-blind, placebo-controlled, crossover method. For methacholine and allergen studies, each subject performed bronchial provocation twice, with a washout interval of seven days. After baseline pulmonary (unction tests (which should be greater than 80 percent of the predicted normal), subjects were instructed to inhale five puffs of either BN52021 or placebo (diluent of BN52021) and pulmonary’ function tests were repeated 10 minutes later.

Table 1—Characteristics of Study Populations

Subjects No. Age,yr FEV,, 1% pred Serum IgE, IU/ml Dp-IgE RAST, % Bound Frequency of Attacks, /yr Methacholine PD20, U
Normal 7 11.8±3.0 98.9±8.2 68 ±52 0.8±0.3 180.4 ±44.2
Asthma
PAF group 7 10.9±2.7 91.6±7.8 1012 ±843 14.7±6.8 9.2 ±2.5 33.4 ±20.5
Methacholinegroup 7 11.0±3.2 92.5±6.9 983 ±614 16.8 ±7.2 8.8 ±3.0 39.4 ±21.2
Allergen group 7 10.5±3.0 92.0 ±6.7 954 ±708 16.3 ±7.7 8.5±2.8 36.7±21.3

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