Allergen-Induced Bronchoconstriction in Asthmatic Children (2)
The leaves of Ginkgo biloba have been used in traditional Chinese medicine for a long time for respiratory diseases. Ginkgolide B (BN52021), the most active PAF antagonist isolated from the trees, has been shown to be a potent inhibitor of PAF-induced thrombocytopenia, bronchoconstriction, and pulmonary anaphylaxis in guinea pigs. buy flovent inhaler
Inhalation may be the optimal route for the administration of antiasthmatic drugs to achieve the maximal therapeutic effect and to reduce the systemic side effects. The purpose of this trial was to examine the effect of aerosolized BN52021 on the immediate bronchoconstriction induced by inhalations of PAF, methacholine, and specific allergen in asthmatic children. The effect of BN52021 on the total counts of WBC, neutrophil, and eosinophil in the peripheral blood induced by PAF inhalation was also studied.
Materials and Methods
Twenty-one stable asthmatic children (16 boys and 5 girls, aged 8 to 15 years old), and 7 age-matched healthy children (5 boys and 2 girls, aged 8 to 15 years old) were studied. All the asthmatic children had elevated serum IgE levels, positive intradermal skin test (dilution of 10~* g/ml, Torii, Japan), and positive radioallergo-sorbent test (RAST) (Pharmacia, Sweden) to the house dust mite, Dermatophagoides pteronyssinus, and eosinophilia (>400 cells/cu mm).